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Most of my snps are like yours. I just found out that I have a 60% blockage in two veins in my heart. I have never had high blood pressure or cholesterol.
I have taken B-total sublingual for 25 years. My doctor told me to quit taking it because it had folic acid in it. People with MTHFR snps should take only Methyl Folate. I looked and looked for why...what is wrong with Folic Acid? The only thing that I could find online is that Folic Acid decreases your fighter genes and lowers your defense against cancer. Is this right?
Folic Acid is cheap and Methyl Folate is expensive.

Have your homocysteine levels been tested? Dr. Lynch always says don't treat SNPs !
If you feel fine it's totally unnecessary to try to treat some SNPs.
Unless you have some clear reasons to believe that your system is out of balance stay away from supplements.

BTW, if you have a CBS C699T mutation any excess homocysteine will be drained away automatically. There is a whole concert of mutations in genes interacting. It's better to leave it to an expert when you feel sick.

That's good-it means your COMT and MAOA won't be fighting! (Wow, that was a groaner, but I couldn't help it.) Do you have a CBS mutation at all, and how many bad copies of MTHFR A1298C do you have? CBS causes low homocysteine, which offsets the high homocysteine caused by MTHFR with a side of COMT.

I have much to learn, but I've never heard of COMT causing high homocysteine by itself [as it affects dopamine, norepi, and serotonin], only in conjunction with a MTHFR mutation (usually C677T; the A1298C variant messes with BH4 levels more than homocysteine, so they say). I tried to access the reference link you listed above but could not get it to load; so sorry. Here is a link to a study that was done on COMT levels and homocysteine with relation to MTHFR mutation. http://www.ncbi.nlm.nih.gov/pubmed/18189241 Incidentally, I have 2 rotten copies of 677, MAOA, and one of COMT, but my homocysteine levels are normal because I also have CBS.

As far as I am aware, no one has figured out a way to induce COMT directly (thus lowering the dopamine levels). If you ... More

That's good-it means your COMT and MAOA won't be fighting! (Wow, that was a groaner, but I couldn't help it.) Do you have a CBS mutation at all, and how many bad copies of MTHFR A1298C do you have? CBS causes low homocysteine, which offsets the high homocysteine caused by MTHFR with a side of COMT.

I have much to learn, but I've never heard of COMT causing high homocysteine by itself [as it affects dopamine, norepi, and serotonin], only in conjunction with a MTHFR mutation (usually C677T; the A1298C variant messes with BH4 levels more than homocysteine, so they say). I tried to access the reference link you listed above but could not get it to load; so sorry. Here is a link to a study that was done on COMT levels and homocysteine with relation to MTHFR mutation. http://www.ncbi.nlm.nih.gov/pubmed/18189241 Incidentally, I have 2 rotten copies of 677, MAOA, and one of COMT, but my homocysteine levels are normal because I also have CBS.

As far as I am aware, no one has figured out a way to induce COMT directly (thus lowering the dopamine levels). If you go to this site: https://www.knowyourgenetics.com/ , you can load your raw data into Amy Yasko's analysis tool (it's free). You may want to follow her protocol-it really, really helped me starting out. I could never seem to take the right combinations of things and felt worse instead of better. Now I know exactly what to take-and what to avoid (e.g., I was taking methylB12, per doctor orders, and I still had B12 deficiency symptoms with sky-high B12 levels. I didn't know hydroxyB12 worked better with my mutations. I also discovered I can't take SAMe but should take methionine instead.) Good luck! Less

My MAOA R297R (rs6323) has the T genotype. This appears to mean I have decreased risk of aggressive behavior.

How is your MAOA R297R? MAOA is known as the warrior gene, and mutants tend to be more aggressive (higher dopamine because it doesn't break down properly). Males have one copy of this gene, and females have two. MAOA and COMT mutations compound each other. Have you had a high serum or urine dopamine level that would suggest that gene is active?