The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. The Val108/158Met variant of the COMT gene has been associated with disorders that affect thought and emotion. For example, researchers have studied this variation as a possible risk factor for bipolar disorder, panic disorder, generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), eating disorders, and attention deficit hyperactivity disorder (ADHD). However, many factors play a part in determining the risk of these complex disorders.
Effexor (Venlafaxine), is an SSRI antidepressant used to treat major depressive disorder, anxiety, and panic disorder. A study conducted in a European American population, indicated a possible pharmacogenetic role for the Val108/158Met variant COMT in antidepressant treatment outcome in patients treated for generalized anxiety disorder with Venlafaxine.1
Venlafaxine, generalized anxiety disorder, Depressive Disorders