Fat and Obesity (FTO) Gene and Risk of Alzheimer's Disease

Alzheimer's disease is the most common cause of dementia. People with dementia may not be able to think well enough to do normal activities, such as getting dressed or eating. They may lose their ability to solve problems or control their emotions. Their personalities may change. They may become agitated or see things that are not there. At present, about 33.9 million people worldwide have Alzheimer's disease, and this is anticipated to triple over the next 40 years2.

Recent studies have demonstrated that polymorphisms in the Fat and Obesity (FTO) gene have strong and robust effects on obesity and obesity-related traits (such as body mass index (BMI). Obesity is a risk factor for elevated insulin levels, hypertension and dyslipidemia, heart disease, and stroke - all of which are reported to be associated with Alzheimer's disease1.