NSAIDs (nonsteroidal anti-inflammatory drugs) relieve fever and pain. They also reduce swelling from arthritis or a muscle sprain or strain. Examples of NSAIDs include: Aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn). When taken for a short time (no longer than 10 days), NSAIDs are safe for most people. Some people may have a higher risk of having a heart attack or a stroke with these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time.
NSAIDs are responsible for 21-25% of reported adverse drug events which include immunological and non immunological hypersensitivity reactions. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions.2
Histamine is released in the allergic response to NSAIDs and is responsible for some of the clinical symptoms. One study found that mutations in genes encoding histamine-metabolizing enzymes may increase the risk, or modify the clinical presentation, of allergic diseases in which histamine plays an important role.1
Ibuprofen, Aspirin, DAO, Uticaria