Response to Narcolepsy Drug - Modafinil

Modafinil (Provigil) is used to treat excessive sleepiness caused by narcolepsy. Modafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). It is in a class of medications called wakefulness promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

Narcolepsy is a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep. People with narcolepsy often find it difficult to stay awake for long periods of time, regardless of the circumstances. Narcolepsy can cause serious disruptions in your daily routine. Sometimes, narcolepsy can be accompanied by a sudden loss of muscle tone (cataplexy) that leads to weakness and loss of muscle control. Cataplexy is often triggered by a strong emotion, most commonly laughter.

This report is based on a study1 which explored the relation between genetic polymorphisms in the ABCB1 gene and clinical response to modafinil and venlafaxine in Narcolepsy.

Related to:
Provigil, narcolepsy, sleep apnea, and shift work sleep disorder, stimulant