Risk of Deep Vein Thrombosis

Deep Vein Thrombosis (DVT) is the formation of a blood clot in a vein deep within the body, usually in the legs. This condition is related to a more severe condition called pulmonary embolism (PE), which occurs if the clot breaks free and travels through the circulatory system to the lungs. DVT always precedes PE. It is estimated that about 250,000 people are hospitalized with venous DVT in the United States each year, but the incidence is probably much higher as many cases go undiagnosed. Pulmonary embolism is potentially life threatening if prompt medical attention is not received. Therefore, recognizing the symptoms of venous DVT and avoiding risk factors is of paramount importance.

Activated protein C is a protein with potent anticoagulant properties. During the normal blood clotting process, Activated protein C limits clot formation. 5% of healthy individuals have resistance to Activated protein C, which is associated with a sevenfold increase in the risk for deep vein thrombosis. Activated protein C resistance is associated with heterozygosity or homozygosity for a single point mutation in the factor V gene (Factor V Leiden)2.

Related to:
DVT, Pulmonary Hypertension, DVT, PE, Blood clots, Venous thromboembolism