Risk of Duodenal Ulcer

A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain starts between meals or during the night; briefly stops if you eat or take antacids; lasts for minutes to hours; comes and goes for several days or weeks. Peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. The most common cause is infection with a bacterium called Helicobacter pylori (H.Pylori). Another cause is the long-term use of nonsteroidal anti-inflammatory medicines (NSAIDs) such as aspirin and ibuprofen. Duodenal ulcers are the type of peptic ulcer that occur on the inside of the upper portion of your small intestine (duodenum)

Genome-wide association analysis (GWAS) have implicated the PSCA and ABO genes in duodenal ulcer. A study1 in the Japanese population showed that PSCA rs2294008 had opposing effects on gastric cancer and duodenal ulcer risk.

Related to:
Peptic ulcer, H. Pylori, Gastric cancer,